6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine

Base Information

• Chemical Name: 6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine
• CAS No.: 672956-49-9
• Molecular Formula: C₃₄H₂₉N₅O₈
• Molecular Weight: 635.633

Synonyms:6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine

Chemical Property of 6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine

There total 7 articles about 6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

6-amino-N6,N6-dibenzoyl-9-{2'-O-benzoyl-3',4'-exo-O-[(4-methoxyphenyl)methylidene]-2-[(prop-2-enyl)oxy]-β-D-ribopyranosyl}purine (672956-48-8) → 6-amino-N6,N6-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine (672956-49-9)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; methanol; at 25 ℃; for 3h;

DOI:10.1002/hlca.200390349

Reference yield:

6-amino-2-chloro-9-(β-D-ribopyranosyl)purine (16755-02-5) → 6-amino-N6,N6-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine (672956-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Cs₂CO₃; 3A MS / 6 h / 90 °C

2.1: pyridine / 0 - 20 °C

2.2: 1.12 g / NaOH; water / tetrahydrofuran; methanol / 0.5 h / 0 °C

3.1: TsOH / dimethylformamide / 2 h / 60 °C

3.2: 72 percent / pyridine / 0 - 20 °C

4.1: 80.7 percent / CF₃COOH / methanol; tetrahydrofuran / 3 h / 25 °C

With pyridine; caesium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390349

Reference yield:

2,6 dichloropurine (5451-40-1) → 6-amino-N6,N6-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine (672956-49-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 90.3 percent / bis(trimethylsilyl)acetamide; TMS-OTf / acetonitrile / 3 h / 70 °C

2.1: 82.6 percent / NH₃ / methanol / 7 h / 100 °C

3.1: Cs₂CO₃; 3A MS / 6 h / 90 °C

4.1: pyridine / 0 - 20 °C

4.2: 1.12 g / NaOH; water / tetrahydrofuran; methanol / 0.5 h / 0 °C

5.1: TsOH / dimethylformamide / 2 h / 60 °C

5.2: 72 percent / pyridine / 0 - 20 °C

6.1: 80.7 percent / CF₃COOH / methanol; tetrahydrofuran / 3 h / 25 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; ammonia; caesium carbonate; toluene-4-sulfonic acid; bis-(trimethylsilyl)acetamide; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/hlca.200390349

upstream raw materials:

6-amino-N⁶,N⁶-dibenzoyl-9-{2'-O-benzoyl-3',4'-exo-O-[(4-methoxyphenyl)methylidene]-2-[(prop-2-enyl)oxy]-β-D-ribopyranosyl}purine

6-amino-2-chloro-9-(β-D-ribopyranosyl)purine

2,6 dichloropurine

6-amino-N⁶-benzoyl-2-[(prop-2-enyl)oxy]-9-(β-D-ribopyranosyl)purine

Downstream raw materials:

Benzoic acid (2R,3R,4R,5R)-2-(2-allyloxy-6-dibenzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-hydroxy-tetrahydro-pyran-3-yl ester

Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 672956-49-9 6-amino-N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)-2-[(prop-2-enyl)oxy]purine

Send

Send

Metric Ton KG G Pound L ML

Send

Send