2'-[18F]fluoro-folic acid

Base Information

Chemical Name:2'-[18F]fluoro-folic acid
CAS No.:1072161-38-6
Molecular Formula:C₁₉H₁₈FN₇O₆
Molecular Weight:458.395
Hs Code.:

Synonyms:2'-[18F]fluoro-folic acid

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Chemical Property of 2'-[18F]fluoro-folic acid

Chemical Property:

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Technology Process of 2'-[18F]fluoro-folic acid

There total 7 articles about 2'-[18F]fluoro-folic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₉⁽¹⁸⁾FN₈O₆

: 1072161-38-6
2'-[18F]fluoro-folic acid

Guidance literature:: C₃₀H₃₉⁽¹⁸⁾FN₈O₆; With hydrogenchloride; water; at 60 ℃; for 0.0833333 - 0.166667h;

With sodium hydroxide; water;

Reference yield:

: 84213-33-2
4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoic acid

: 1072161-38-6
2'-[18F]fluoro-folic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.25 h / 20 °C

1.2: 20.5 h / 20 °C

2.1: pyrrolidine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: N,N-dimethyl acetamide / 13 h / 60 °C

4.1: N,N-dimethyl-formamide / 20 h / 20 °C

5.1: K[¹⁸F]F–K₂₂₂ complex / N,N-dimethyl-formamide / 0.33 h / 140 - 145 °C

6.1: hydrogenchloride; water / 0.08 - 0.17 h / 60 °C

With pyrrolidine; hydrogenchloride; K[¹⁸F]F–K₂₂₂ complex; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1072161-32-0
di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

: 1072161-38-6
2'-[18F]fluoro-folic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyrrolidine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: N,N-dimethyl acetamide / 13 h / 60 °C

3: N,N-dimethyl-formamide / 20 h / 20 °C

4: K[¹⁸F]F–K₂₂₂ complex / N,N-dimethyl-formamide / 0.33 h / 140 - 145 °C

5: hydrogenchloride; water / 0.08 - 0.17 h / 60 °C

With pyrrolidine; hydrogenchloride; K[¹⁸F]F–K₂₂₂ complex; water; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;