di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate
CAS No.:1072161-32-0
Molecular Formula:C₃₅H₃₉N₃O₉
Molecular Weight:645.709
Hs Code.:

Synonyms:di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

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Chemical Property of di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

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Technology Process of di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

There total 3 articles about di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 84213-33-2
4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoic acid

: 16874-06-9
di-tert-butyl L-glutamate

: 1072161-32-0
di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

Guidance literature:: 4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

di-tert-butyl L-glutamate; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1055/s-0030-1260247

Reference yield:

: 144313-55-3,200616-62-2
H-L-Glu-OtBu*HCl

: 84213-33-2
4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoic acid

: 1072161-32-0
di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

Guidance literature:: 4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.25h;

H-L-Glu-OtBu*HCl; With triethylamine; In dichloromethane; at 20 ℃; for 20.5h;

Reference yield:

: 610-36-6
4-amino-2-nitrobenzoic acid

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1072161-32-0
di-tert-butyl N-(4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-nitrobenzoyl)-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / 1,4-dioxane; water / 20 h / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

With sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1055/s-0030-1260247