Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

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Chemical Name:Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate
CAS No.:937055-91-9
Molecular Formula:C₂₉H₃₀ClN₃O₅
Molecular Weight:536.027
Hs Code.:

Synonyms:Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

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Chemical Property of Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

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Technology Process of Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

There total 9 articles about Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate

: 28782-45-8
(1H-imidazol-4-yl)-acetic acid ethyl ester

: 937055-91-9
Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

Guidance literature:: With potassium carbonate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937055-91-9
Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: toluene / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.2: 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 937054-13-2
methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

: 937055-91-9
Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-imidazol-4-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Resolution of racemate

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

2.2: 3 h / 0 °C

3.1: triethylamine / dichloromethane / 3 h / 0 °C

4.1: potassium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 2 h / 80 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;