ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Base Information

Chemical Name:ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate
CAS No.:1415991-98-8
Molecular Formula:C₂₂H₂₃FN₂O₅S
Molecular Weight:446.499
Hs Code.:

Synonyms:ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

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Chemical Property of ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

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Technology Process of ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

There total 7 articles about ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(piperidin-4-yl)benzo[d]oxazole 2,2,2-trifluoroacetate

: 541-41-3
chloroformic acid ethyl ester

: 1415991-98-8
ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Guidance literature:: 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(piperidin-4-yl)benzo[d]oxazole 2,2,2-trifluoroacetate; With triethylamine; In dichloromethane; at 25 - 28 ℃; for 0.5h;

chloroformic acid ethyl ester; In dichloromethane; at 25 - 28 ℃; for 0.5h;

Reference yield:

: 142994-04-5
2-fluoro-4-(methylsulphonyl)benzoic acid

: 1415991-98-8
ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

5.1: dichloromethane / 3 h / 25 - 28 °C

6.1: triethylamine / dichloromethane / 0.5 h / 25 - 28 °C

6.2: 0.5 h / 25 - 28 °C

With hydrogen; potassium acetate; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 40925-68-6
2-amino-4-bromo-phenol

: 1415991-98-8
ethyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

5.1: dichloromethane / 3 h / 25 - 28 °C

6.1: triethylamine / dichloromethane / 0.5 h / 25 - 28 °C

6.2: 0.5 h / 25 - 28 °C

With hydrogen; potassium acetate; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;