N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

Base Information

Chemical Name:N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine
CAS No.:1361298-17-0
Molecular Formula:C₂₂H₂₀N₄O₃
Molecular Weight:388.426
Hs Code.:

Synonyms:N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

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Technology Process of N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

There total 7 articles about N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1361298-24-9
8-bromo-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazine

: 102-56-7,102526-87-4
2,5-dimethoxyaniline

: 1361298-17-0
N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 100 ℃; for 4h; Inert atmosphere;
DOI:10.1055/s-0031-1289613

Reference yield:

: 94-30-4
ethyl 4-methoxybenzoate

: 1361298-17-0
N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / mineral oil / 1 h / 70 °C / Inert atmosphere

2: hydrogenchloride / water; dimethyl sulfoxide / 24 h / 20 °C / Inert atmosphere

3: sodium acetate; acetic acid / 4.5 h / 20 °C / Reflux; Inert atmosphere

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 4 h / 100 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium acetate; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium t-butanolate; In water; dimethyl sulfoxide; toluene; mineral oil; 2: Pummerer reaction / 4: Buchwald reaction;
DOI:10.1055/s-0031-1289613

Reference yield:

: 13603-51-5
2-hydroxy-1-(4-methoxyphenyl)-2-(methylsulfanyl)ethan-1-one

: 1361298-17-0
N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate; acetic acid / 4.5 h / 20 °C / Reflux; Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 4 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium t-butanolate; In toluene; 2: Buchwald reaction;
DOI:10.1055/s-0031-1289613