2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Name:2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:865436-12-0
Molecular Formula:C₃₂H₄₅N₅O₈
Molecular Weight:627.738
Hs Code.:

2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

Synonyms:2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Property of 2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of 2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

There total 1 articles about 2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 865436-09-5
2S,4R-4-carboxymethoxy-2-(pyridin-2-ylaminomethyl)pyrrolidine-1-carboxylic acid benzyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 182618-30-0
Nα-(9-fluorenylmethoxycarbonyloxy)-β-amino-L-alanine tertbutyl ester

: 865436-12-0
2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: 2S,4R-4-carboxymethoxy-2-(pyridin-2-ylaminomethyl)pyrrolidine-1-carboxylic acid benzyl ester; Nα-(9-fluorenylmethoxycarbonyloxy)-β-amino-L-alanine tertbutyl ester; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2.5h;

di-tert-butyl dicarbonate; With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 46.0%

: 865436-12-0
2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

: 98-09-9
benzenesulfonyl chloride

: 76-05-1
trifluoroacetic acid

: 865436-05-1
2S,4R,20S-4-[(2-benzenesulfonylamino-2-carboxy-ethylcarbamoyl)-methoxy]-2-(pyridin-2-ylaminomethyl)-pyrrolidine-1-carboxylic acid benzyl ester TFA-salt

Guidance literature:: 2S,4R,20S-4-[(2-amino-2-tert-butoxycarbonyl-ethylcarbamoyl)-methoxy]-2-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester; benzenesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

trifluoroacetic acid; at 20 ℃; for 2h;