2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

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Chemical Name:2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate
CAS No.:910864-35-6
Molecular Formula:C₆₃H₆₄O₁₅P₂
Molecular Weight:1123.14
Hs Code.:

Synonyms:2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

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Chemical Property of 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

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Technology Process of 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

There total 7 articles about 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 910864-43-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 910864-35-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

Guidance literature:: 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate; Dibenzyl N,N-diisopropylphosphoramidite; With 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 15h;

With dihydrogen peroxide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jo0610816

Reference yield:

: 2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-1,3,5-O-orthoformate

: 910864-35-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 55 percent / aq. HCl / methanol / 18 h / 20 °C

2.1: 53 percent / Et₃N / BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe / toluene

3.1: 36 percent / iPr₂NEt / tetrahydrofuran / 24 h / 50 °C

4.1: 4,5-dicyanoimidazole / CH₂Cl₂ / 15 h / 20 °C

4.2: 81 percent / aq. H₂O₂ / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; 4,5-dicyano-1H-imidazole; triethylamine; N-ethyl-N,N-diisopropylamine; BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo0610816

Reference yield:

: 910864-22-1
2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol

: 910864-35-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol 3-diphenyl phosphate 5-dibenzyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 53 percent / Et₃N / BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe / toluene

2.1: 36 percent / iPr₂NEt / tetrahydrofuran / 24 h / 50 °C

3.1: 4,5-dicyanoimidazole / CH₂Cl₂ / 15 h / 20 °C

3.2: 81 percent / aq. H₂O₂ / CH₂Cl₂ / 1 h / 0 °C

With 4,5-dicyano-1H-imidazole; triethylamine; N-ethyl-N,N-diisopropylamine; BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo0610816