2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

Base Information

Chemical Name:2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate
CAS No.:910864-43-6
Molecular Formula:C₄₉H₅₁O₁₂P
Molecular Weight:862.91
Hs Code.:

Synonyms:2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

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Chemical Property of 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

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Technology Process of 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

There total 6 articles about 2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 910864-23-2
2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

: 3587-60-8
Benzyloxymethyl chloride

: 910864-43-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 24h;
DOI:10.1021/jo0610816

Reference yield:

: 2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-1,3,5-O-orthoformate

: 910864-43-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / aq. HCl / methanol / 18 h / 20 °C

2: 53 percent / Et₃N / BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe / toluene

3: 36 percent / iPr₂NEt / tetrahydrofuran / 24 h / 50 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo0610816

Reference yield:

: 910864-22-1
2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol

: 910864-43-6
2-O-benzyl-1-O-benzyloxymethyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / Et₃N / BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe / toluene

2: 36 percent / iPr₂NEt / tetrahydrofuran / 24 h / 50 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe; In tetrahydrofuran; toluene;
DOI:10.1021/jo0610816