tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

Base Information

Chemical Name:tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate
CAS No.:1613450-01-3
Molecular Formula:C₂₅H₄₀N₂O₆S
Molecular Weight:496.668
Hs Code.:

Synonyms:tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

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Chemical Property of tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

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Technology Process of tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

There total 16 articles about tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₄₀N₂O₉S₂

: 1613450-01-3
tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

Guidance literature:: With sodium dihydrogenphosphate; In water; ethyl acetate; acetonitrile; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2014.05.004

Reference yield:

: C₃₀H₄₂N₂O₉S₂

: 1613450-01-3
tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

Guidance literature:: With sodium dihydrogenphosphate; In water; ethyl acetate; acetonitrile; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2014.05.004

Reference yield:

: 5333-86-8
ethyl benzimidate hydrochloride

: 1613450-01-3
tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-ethylpropanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / dichloromethane; water

1.2: 2 h / Reflux

2.1: sodium hydroxide / water; methanol; acetone / 3.33 h / 2 °C / Cooling with ice

3.1: hydrogenchloride / water / 1 h / 0 °C / pH < 3

4.1: dmap / dichloromethane; tert-butyl alcohol / 1 h / Inert atmosphere; Reflux

5.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; toluene / 0 - 20 °C / Inert atmosphere

6.1: sodium cyanoborohydride / acetic acid / 16 h / 0 - 20 °C

7.1: 1H-imidazole; triethylamine; thionyl chloride / dichloromethane / 2.5 h / -10 - 20 °C / Inert atmosphere

8.1: rhodium(III) chloride hydrate; sodium periodate / water; acetonitrile / 4.25 h / 0 - 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C / Inert atmosphere

10.1: sodium dihydrogenphosphate / water; acetonitrile; ethyl acetate / 2 h / 50 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; dmap; sodium periodate; sodium dihydrogenphosphate; thionyl chloride; rhodium(III) chloride hydrate; tetrabutylammomium bromide; sodium cyanoborohydride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; water; acetic acid; ethyl acetate; acetone; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tet.2014.05.004