Technology Process of tert-butyl 3,4-dibenzyl-2-oxo-1,2,3-oxathiazolidine-4-carboxylate
There total 8 articles about tert-butyl 3,4-dibenzyl-2-oxo-1,2,3-oxathiazolidine-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole; thionyl chloride; triethylamine;
In
dichloromethane;
at -10 - 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1016/j.tet.2014.05.004
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate / dichloromethane; water
1.2: 2 h / Reflux
2.1: sodium hydroxide / water; methanol; acetone / 3.33 h / 2 °C / Cooling with ice
3.1: hydrogenchloride / water / 1 h / 0 °C / pH < 3
4.1: dmap / dichloromethane; tert-butyl alcohol / 1 h / Inert atmosphere; Reflux
5.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; toluene / 0 - 20 °C / Inert atmosphere
6.1: sodium cyanoborohydride / acetic acid / 16 h / 0 - 20 °C
7.1: 1H-imidazole; triethylamine; thionyl chloride / dichloromethane / 2.5 h / -10 - 20 °C / Inert atmosphere
With
1H-imidazole; hydrogenchloride; dmap; thionyl chloride; tetrabutylammomium bromide; sodium cyanoborohydride; sodium carbonate; triethylamine; potassium hydroxide; sodium hydroxide;
In
methanol; dichloromethane; water; acetic acid; acetone; toluene; tert-butyl alcohol;
DOI:10.1016/j.tet.2014.05.004
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: acetyl chloride / diethyl ether / 0.75 h / 0 °C / Inert atmosphere
1.2: 730.5 h / 2 °C / Inert atmosphere
2.1: sodium carbonate / dichloromethane; water
2.2: 2 h / Reflux
3.1: sodium hydroxide / water; methanol; acetone / 3.33 h / 2 °C / Cooling with ice
4.1: hydrogenchloride / water / 1 h / 0 °C / pH < 3
5.1: dmap / dichloromethane; tert-butyl alcohol / 1 h / Inert atmosphere; Reflux
6.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; toluene / 0 - 20 °C / Inert atmosphere
7.1: sodium cyanoborohydride / acetic acid / 16 h / 0 - 20 °C
8.1: 1H-imidazole; triethylamine; thionyl chloride / dichloromethane / 2.5 h / -10 - 20 °C / Inert atmosphere
With
1H-imidazole; hydrogenchloride; dmap; thionyl chloride; tetrabutylammomium bromide; sodium cyanoborohydride; sodium carbonate; triethylamine; acetyl chloride; potassium hydroxide; sodium hydroxide;
In
methanol; diethyl ether; dichloromethane; water; acetic acid; acetone; toluene; tert-butyl alcohol;
1.1: |Pinner Amidine Synthesis / 1.2: |Pinner Imino Ether Synthesis;
DOI:10.1016/j.tet.2014.05.004
