4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Base Information

Chemical Name:4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate
CAS No.:1073549-11-7
Molecular Formula:C₂HF₃O₂*C₂₈H₃₄FN₃O₄S
Molecular Weight:641.684
Hs Code.:

4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Synonyms:4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Suppliers and Price of 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

There total 17 articles about 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1073549-09-3
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester.

: 76-05-1
trifluoroacetic acid

: 1073549-11-7
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00462

Reference yield:

: 1073549-12-8
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 1073549-11-7
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Guidance literature:: 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid; With methanol; sodium methylate; at 0 ℃; for 0.333333h; Inert atmosphere;

With hydrogenchloride; In water;

trifluoroacetic acid; In water; acetonitrile; preparative HPLC;

Reference yield:

: 55666-42-7
tert-butyl 2-bromobenzoate

: 1073549-11-7
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; water / 17 h / 90 °C / Inert atmosphere

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 90 °C

5.1: pyridine; hydroxylamine / water

6.1: hydrogen / palladium / ethanol / 1 h

7.1: sodium cyanoborohydride; ammonium acetate / methanol / 0.25 h / 0 °C

7.2: 4.17 h / 0 - 20 °C

8.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 0 °C

8.2: 2 h / 0 - 20 °C

9.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

10.1: sodium methylate / methanol / 0.33 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; ammonium acetate; hydrogen; hydroxylamine; sodium methylate; sodium cyanoborohydride; sodium carbonate; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium; In methanol; tetrachloromethane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;