4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Base Information

Chemical Name:4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid
CAS No.:1073549-12-8
Molecular Formula:C₃₀H₃₆FN₃O₅S
Molecular Weight:569.697
Hs Code.:

Synonyms:4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

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Chemical Property of 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

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Technology Process of 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

There total 18 articles about 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160135-46-6
(S)-2-acetylsulfanyl-4-methylpentanoic acid dicyclohexylamine salt

: 1073549-05-9
4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

: 1073549-12-8
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Guidance literature:: (S)-2-acetylsulfanyl-4-methylpentanoic acid dicyclohexylamine salt; 4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); In dichloromethane; at 0 - 2 ℃;

With sodium hydrogencarbonate; In dichloromethane; for 0.25h;

With hydrogenchloride; In Isopropyl acetate; water; for 1h; pH=5.5;

Reference yield:

: 1073549-09-3
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester.

: 1073549-12-8
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 55666-42-7
tert-butyl 2-bromobenzoate

: 1073549-12-8
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; water / 46 h / 90 °C / Inert atmosphere

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 7 h / 90 °C / Inert atmosphere

3: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 27 °C

4: caesium carbonate / palladium diacetate; catacxium A / toluene; water / 16 h / 90 °C / Inert atmosphere

5: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 24 h / 40 °C

6: hydrogen; ammonium hydroxide / Raney nickel / ethanol / 3 h / 760.05 Torr

7: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / dichloromethane / -2 - 3 °C

8: trifluoroacetic acid / dichloromethane / 16 h / 15 - 20 °C

With ammonium hydroxide; N-Bromosuccinimide; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; trifluoroacetic acid; sodium hydroxide; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; palladium diacetate; catacxium A; In tetrachloromethane; ethanol; dichloromethane; water; isopropyl alcohol; toluene;