(E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene

Base Information

• Chemical Name: (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene
• CAS No.: 321155-49-1
• Molecular Formula: C₂₁H₂₇NOSi
• Molecular Weight: 337.537
• Mol file: 321155-49-1.mol

Synonyms:(E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene

Chemical Property of (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene

There total 4 articles about (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Iodoacetophenone (13329-40-3) + (E)-1-dimethyl(2-pyridyl)silyl-1-octene (424822-13-9) → (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene (321155-49-1)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trifuran-2-yl-phosphane; triethylamine; In tetrahydrofuran; at 50 ℃; for 24h;

DOI:10.1021/ja002582q

Reference yield:

4-Iodoacetophenone (13329-40-3) + dimethylhexenyl(2-pyridyl)silane → (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene (321155-49-1)

Guidance literature:

With palladium diacetate; trifuran-2-yl-phosphane; triethylamine; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1021/ja016790+

Reference yield:

2-bromo-pyridine (109-04-6) → (E)-α-butyl-β-(2-pyridyldimethylsilyl)-4-acetylstyrene (321155-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: butyllithium / diethyl ether; hexane / -78 °C

1.2: diethyl ether; hexane / -78 - 20 °C

2.1: 90 percent / Et₃N; tri-2-furylphosphine; Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 24 h / 50 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; n-butyllithium; trifuran-2-yl-phosphane; triethylamine; In tetrahydrofuran; diethyl ether; hexane; 2.1: Heck coupling;

DOI:10.1021/ja002582q

upstream raw materials:

4-Iodoacetophenone

(E)-1-dimethyl(2-pyridyl)silyl-1-octene

2-bromo-pyridine

1-chloro(dimethyl)silyl-1-octene