O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

Base Information

Chemical Name:O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate
CAS No.:57538-75-7
Molecular Formula:C₃₁H₃₂FN₂O₉P
Molecular Weight:626.575
Hs Code.:

Synonyms:O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

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Chemical Property of O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

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Technology Process of O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

There total 8 articles about O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 171081-14-4
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridate

: 57538-75-7
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

Guidance literature:: In acetonitrile; at 80 ℃; for 2h;
DOI:10.1039/b413552k

Reference yield:

: 171081-10-0
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridite

: 57538-75-7
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / tert-butyl hydroperoxide / tetrahydrofuran / 1 h / 20 °C

2: 96 percent / acetonitrile / 2 h / 80 °C

With tert.-butylhydroperoxide; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b413552k

Reference yield:

: 162611-40-7,162611-41-8,171081-08-6
5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite

: 57538-75-7
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Me₃SiCl / tetrahydrofuran / 1 h

2: 98 percent / tert-butyl hydroperoxide / tetrahydrofuran / 1 h / 20 °C

3: 96 percent / acetonitrile / 2 h / 80 °C

With tert.-butylhydroperoxide; chloro-trimethyl-silane; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b413552k