O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

Base Information

Chemical Name:O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate
CAS No.:171081-16-6
Molecular Formula:C₃₄H₃₅FN₃O₉P
Molecular Weight:679.639
Hs Code.:

Synonyms:O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

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Chemical Property of O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

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Technology Process of O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

There total 3 articles about O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 171081-12-2
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

: 171081-16-6
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

Guidance literature:: With tert.-butylhydroperoxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1039/b103082p

Reference yield:

: 162611-40-7,162611-41-8,171081-08-6
5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite

: 171081-16-6
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / tetrazole / acetonitrile / 0.17 h / Ambient temperature

2: tert-butyl hydroperoxide

With 1H-tetrazole; tert.-butylhydroperoxide; In acetonitrile;
DOI:10.1246/cl.1995.727

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 171081-16-6
O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / TMSCl / tetrahydrofuran / 1 h / 20 °C

2: 98 percent / tert-butyl hydroperoxide / tetrahydrofuran / 1 h / 20 °C

With tert.-butylhydroperoxide; chloro-trimethyl-silane; In tetrahydrofuran;
DOI:10.1039/b103082p