Phentermine

Base Information

• Chemical Name: Phentermine
• CAS No.: 122-09-8
• Deprecated CAS: 12674-13-4,9008-94-0,9008-94-0
• Molecular Formula: C10H15 N
• Molecular Weight: 149.236
• European Community (EC) Number: 204-522-1
• NSC Number: 759163
• UN Number: 1851
• UNII: C045TQL4WP
• DSSTox Substance ID: DTXSID9023461
• Nikkaji Number: J5.348A
• Wikipedia: Phentermine
• Wikidata: Q418157
• NCI Thesaurus Code: C61890
• RXCUI: 8152
• Pharos Ligand ID: ZQWSNQ2S1W3T
• Metabolomics Workbench ID: 42599
• ChEMBL ID: CHEMBL1574
• Mol file: 122-09-8.mol

Synonyms:Adipex P;Adipex-P;AdipexP;Duromine;Hydrochloride, Phentermine;Ionamine;Phentermine;Phentermine Hydrochloride

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Phentermine

Chemical Property:

• Vapor Pressure: 0.243mmHg at 25°C
• Melting Point: 143°C (estimate)
• Refractive Index: 1.523
• Boiling Point: 206 °C at 760 mmHg
• PKA: pKa 10.11 (Uncertain)
• Flash Point: 93.1 °C
• PSA: 26.02000
• Density: 0.938 g/cm³
• LogP: 2.66670
• Storage Temp.: Store at 0-5°C
• Water Solubility.: 18.6g/L at 25℃
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 112
• Transport DOT Label: Poison

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,T,F
• Statements: 20/21/22-36/37/38-40-39/23/24/25-23/24/25-11-67
• Safety Statements: 26-36/37/39-36/37-24/25-23-45-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Weight Loss Agents
• Canonical SMILES: CC(C)(CC1=CC=CC=C1)N
• Recent ClinicalTrials: A Study of VI-0521 on Ambulatory Blood Pressure in Overweight or Obese Subjects
• Uses: Appetite suppressant (systemic).
• Therapeutic Function: Antiobesity

Technology Process of Phentermine

There total 37 articles about Phentermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2-methyl-2-nitropropyl)benzene (34405-43-1) → Phentermin (122-09-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 40 ℃; for 24h;

DOI:10.1021/ja304561c

Reference yield: 95.0%

C20H27NO3S → Phentermin (122-09-8)

Guidance literature:

With pyridine; In water; acetonitrile; at 75 ℃;

DOI:10.1021/jacs.1c03872

Reference yield: 88.0%

2,2-dimethyl-3-phenylpropanoic acid (5669-14-7) → Phentermin (122-09-8)

Guidance literature:

2,2-dimethyl-3-phenylpropanoic acid; With diphenyl phosphoryl azide; triethylamine; In acetonitrile; at 50 ℃; for 2h;

With hydrogenchloride; water; In acetonitrile; for 16h; Reflux;

DOI:10.1016/j.bmc.2021.116215

upstream raw materials:

N,N'-bis-(1,1-dimethyl-2-phenyl-ethyl)-urea

N-(1,1-dimethyl-2-phenyl-ethyl)-formamide

1-amino-2-(2-amino-2-methylpropyl)benzene

α-(1-amino-1-methylethyl)benzenemethanol

Downstream raw materials:

nicotinic acid-(1,1-dimethyl-2-phenyl-ethylamide)

N-(2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine

2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide

1-t-Butyl-3-(2-methyl-1-phenyl-2-propyl)-harnstoff

Refernces

• 1、 Marquardt,Edwards. "Reductive synthesis of , -dimethylphenethylamine.". . p. 1861 - 1863. Retrieved 1972.
• 2、 Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei. "Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination". supporting information. p. 9875 - 9880. Retrieved 2021/03/29.