2-Amino-2-methyl-1-phenylpropan-1-ol

Base Information

• Chemical Name: 2-Amino-2-methyl-1-phenylpropan-1-ol
• CAS No.: 34405-42-0
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Hs Code.: 2922199090
• European Community (EC) Number: 868-408-9
• NSC Number: 17705
• DSSTox Substance ID: DTXSID701274455
• Nikkaji Number: J50.947G
• Mol file: 34405-42-0.mol

Synonyms:2-amino-2-methyl-1-phenylpropan-1-ol;34405-42-0;USAF CS-8;2-Phenyl-1,1-dimethylethanolamine;2-Amino-2-methyl-1-phenyl-1-propanol;NSC 17705;BRN 2802507;1-Propanol, 2-amino-2-methyl-1-phenyl-;Benzenemethanol, alpha-(1-amino-1-methylethyl)-;alpha-(1-amino-1-methylethyl)benzenemethanol;2-AMINO-2-METHYL-1-PHENYL-PROPAN-1-OL;3-13-00-01799 (Beilstein Handbook Reference);Benzenemethanol, .alpha.-(1-amino-1-methylethyl)-;NSC17705;SCHEMBL411887;DTXSID701274455;1phenyl-2-methyl-2-amino-propanol;NSC-17705;AKOS006279578;AT30646;SB76713;LS-121678;CS-0247814;EN300-374045;Z1198157843

Chemical Property of 2-Amino-2-methyl-1-phenylpropan-1-ol

Chemical Property:

• Vapor Pressure: 0.000709mmHg at 25°C
• Melting Point: 100-101 °C
• Boiling Point: 295°Cat760mmHg
• PKA: 12.09±0.50(Predicted)
• Flash Point: 132.2°C
• PSA: 46.25000
• Density: 1.05g/cm³
• LogP: 2.15760
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

99% ^*data from raw suppliers

β-HydroxylPhentermine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(C1=CC=CC=C1)O)N
• Uses: β-Hydroxyl Phentermine is derived from 2-Nitropropane (N519600), which is an oxidative stress-inducing agent and also a carcinogen. It is used in the induction of DNA polymerase β-dependent base excision repair in response to oxidative stress in the liver.

Technology Process of 2-Amino-2-methyl-1-phenylpropan-1-ol

There total 9 articles about 2-Amino-2-methyl-1-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(2-hydroxy-1,1-dimethyl-2-phenylethyl)hydroxylamine (68385-34-2) → α-(1-amino-1-methylethyl)benzenemethanol (34405-42-0)

Guidance literature:

With phosphate buffer; potassium chloride; In ethanol; at 30 ℃; cotrolled potential electrolysis, cathod: Hg, vs. S_.C_.E_.;

Reference yield: 66.0%

1-phenyl-2-methyl-2-nitropropanol (33687-74-0) → α-(1-amino-1-methylethyl)benzenemethanol (34405-42-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 5h; Heating;

DOI:10.1002/hlca.19810640732

Reference yield: 64.0%

1-phenyl-2-methyl-2-nitropropanol (33687-74-0) → N-(2-hydroxy-1,1-dimethyl-2-phenylethyl)hydroxylamine (68385-34-2) + α-(1-amino-1-methylethyl)benzenemethanol (34405-42-0)

Guidance literature:

With citrate buffer; potassium chloride; In ethanol; at 30 ℃; cotrolled potential electrolysis, cathod: Hg, vs. S_.C_.E_.;

upstream raw materials:

N-(2-hydroxy-1,1-dimethyl-2-phenylethyl)hydroxylamine

1-phenyl-2-methyl-2-nitropropanol

1,1-Dimethyl-2-phenyl-2-trimethylsilanyloxy-ethylamine

2,2,2-Trifluoro-N-(2-hydroxy-1,1-dimethyl-2-phenyl-ethyl)-acetamide

Downstream raw materials:

tert-butyl N-[2-methyl-1-(4-nitrophenyl)-2-propyl]carbamate

N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine

C₂₁H₂₉N₃O₄S

C₂₁H₂₇N₃O₆S

Refernces

• 1、 -. "INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS". Page/Page column 41. . Retrieved 2008/12/05.
• 2、 Nordlander, Eric J.,Payne, Mark J.,Njoroge, George F.,Balk, Michael A.,Laikos George D.,Vishwanath, Vasanth M.. "Friedel-Crafts Acylation with N-(Trifluoroacetyl)-α-amino Acid Chlorides. Application to the Preparation of β-Arylalkylamines and 3-Substituted 1,2,3,4-Tetrahydroisoquinolines". . p. 4107 - 4111. Retrieved 2007/10/02.