6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone

Base Information

• Chemical Name: 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone
• CAS No.: 193965-13-8
• Molecular Formula: C₂₈H₂₆FNO₃S
• Molecular Weight: 475.584
• Mol file: 193965-13-8.mol

Synonyms:6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone

Chemical Property of 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone

There total 6 articles about 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

conc NH4 OH + water (7732-18-5) + 4-fluorobenzoyl chloride (403-43-0) + 6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (193964-15-7) → 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone (193965-13-8)

Guidance literature:

With sodium hydroxide; AlCl₃; In methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) → 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone (193965-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / benzene

2: sodium hydroxide / AlCl₃ / methanol; dichloromethane; 1,2-dichloro-ethane

With sodium hydroxide; sodium carbonate; AlCl₃; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In methanol; dichloromethane; 1,2-dichloro-ethane; benzene;

Reference yield:

6-methoxy-benzo[b]thiophene (90560-10-4) → 6-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 4-Fluorophenyl Ketone (193965-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, 2.) (i-PrO)3B, 3.) 2.5N HCl, 4.) (Ph₃P)4Pd, Na₂CO₃

2: AlCl₃ / 1,2-dichloro-ethane

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; aluminium trichloride; Triisopropyl borate; sodium carbonate; In 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(99)00076-1

upstream raw materials:

4-fluorobenzoyl chloride

6-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene

6-methoxy-benzo[b]thiophene

3-methoxybenzenethiol