racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

Base Information

Chemical Name:racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide
CAS No.:113661-24-8
Molecular Formula:C₂₅H₃₁NO₇
Molecular Weight:457.524
Hs Code.:

Synonyms:racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

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Chemical Property of racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

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Technology Process of racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

There total 32 articles about racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89464-18-6
(+/-)-2-methyl-4-pentenenitrile

: 113661-24-8
trans-racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

Guidance literature:: Multi-step reaction with 9 steps

3: 420 mg / ammonia / tetrahydrofuran; H₂O / -75 °C

4: 80 percent / sodium ethoxyde / ethanol / 1.5 h / 20 °C

5: 250 mg / 0.3M hydrochloric acid / H₂O / 3 h / Heating

6: 1.) di-isopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, 18 deg C, 16 h

7: sodium hydride / tetrahydrofuran / 6 h / 18 °C

8: tetrahydrofuran / 0.75 h / 18 °C

9: tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) 0 deg C, 2.) 18 deg C, 12 h

With hydrogenchloride; ammonia; sodium ethanolate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;

Reference yield:

: 89464-18-6
(+/-)-2-methyl-4-pentenenitrile

: 113661-24-8
cis-racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

Guidance literature:: Multi-step reaction with 9 steps

3: 420 mg / ammonia / tetrahydrofuran; H₂O / -75 °C

4: 80 percent / sodium ethoxyde / ethanol / 1.5 h / 20 °C

5: 250 mg / 0.3M hydrochloric acid / H₂O / 3 h / Heating

6: 1.) di-isopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, 18 deg C, 16 h

7: sodium hydride / tetrahydrofuran / 6 h / 18 °C

8: tetrahydrofuran / 0.75 h / 18 °C

9: tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) 0 deg C, 2.) 18 deg C, 12 h

With hydrogenchloride; ammonia; sodium ethanolate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;

Reference yield:

: 113661-27-1
(RS)-methyl 3-cyano-3-methylhex-5-enoate

: 113661-24-8
cis-racemic-2-allyl-N-benzyloxymethyl-3-(2-methoxycarbonyl-2-t-butoxycarbonylethylidene)-2-methylsuccinimide

Guidance literature:: Multi-step reaction with 8 steps

2: 420 mg / ammonia / tetrahydrofuran; H₂O / -75 °C

3: 80 percent / sodium ethoxyde / ethanol / 1.5 h / 20 °C

4: 250 mg / 0.3M hydrochloric acid / H₂O / 3 h / Heating

5: 1.) di-isopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, 18 deg C, 16 h

6: sodium hydride / tetrahydrofuran / 6 h / 18 °C

7: tetrahydrofuran / 0.75 h / 18 °C

8: tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) 0 deg C, 2.) 18 deg C, 12 h

With hydrogenchloride; ammonia; sodium ethanolate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;