Technology Process of {3,5-bis[1-(4-methoxyphenyl)-1-methylethyl]hepta-3,4-diene-1,6-diyn-1-yl}(triisopropyl)silane
There total 9 articles about {3,5-bis[1-(4-methoxyphenyl)-1-methylethyl]hepta-3,4-diene-1,6-diyn-1-yl}(triisopropyl)silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 14h;
DOI:10.1002/ejoc.200700373
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 91 percent / KOH; water / ethane-1,2-diol / 38 h / Heating
2.1: Et3N; methanesulfonyl chloride / tetrahydrofuran / 0.17 h / 0 °C
2.2: 80 percent / tetrahydrofuran / 1 h / 0 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
3.2: 82 percent / tetrahydrofuran; hexane / -78 - 20 °C
4.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C
4.2: 99 percent / tetrahydrofuran / -78 °C
5.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C
5.2: 93 percent / tetrahydrofuran / -78 - 20 °C
6.1: 46 percent / CuI; Pd(PPh3)4; Huenig base / 1,2-dichloro-ethane / 80 °C
7.1: 97 percent / K2CO3 / methanol; tetrahydrofuran / 14 h / 20 °C
With
potassium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; water; sodium hexamethyldisilazane; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; hexane; ethylene glycol; 1,2-dichloro-ethane;
6.1: Sonogashira cross-coupling reaction;
DOI:10.1002/ejoc.200700373
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nBuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C
1.2: 99 percent / tetrahydrofuran / -78 °C
2.1: NaHDMS / tetrahydrofuran / 0.5 h / -78 - 20 °C
2.2: 93 percent / tetrahydrofuran / -78 - 20 °C
3.1: 46 percent / CuI; Pd(PPh3)4; Huenig base / 1,2-dichloro-ethane / 80 °C
4.1: 97 percent / K2CO3 / methanol; tetrahydrofuran / 14 h / 20 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; sodium hexamethyldisilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane;
3.1: Sonogashira cross-coupling reaction;
DOI:10.1002/ejoc.200700373
![{3,5-bis[1-(4-methoxyphenyl)-1-methylethyl]-7-[triethylsilyl]hepta-3,4-diene-1,6-diyn-1-yl}(triisopropyl)silane](/Databaselist/images/loading.webp)
