ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

Base Information

Chemical Name:ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate
CAS No.:1374400-19-7
Molecular Formula:C₂₃H₂₅N₃O₇S₂
Molecular Weight:519.599
Hs Code.:

Synonyms:ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

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Chemical Property of ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

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Technology Process of ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

There total 3 articles about ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₃N₂O₄S₂^(1-)*K⁽¹⁺⁾

: 26226-72-2
4-[(chloroacetyl)amino]-benzoic acid, ethyl ester

: 1374400-19-7
ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

Guidance literature:: In ethanol; water; for 0.0166667h; Reflux;
DOI:10.1016/j.tet.2013.09.025

Reference yield:

: 15029-45-5
2-cyano-N-(3-methoxy-propyl) acetamide

: 1374400-19-7
ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol / 0.33 h / 10 °C

2.1: ethanol; water / 1 h

2.2: 2.7 h / Reflux

3.1: ethanol; water / 0.02 h / Reflux

With potassium hydroxide; In ethanol; water;
DOI:10.1016/j.tet.2013.09.025

Reference yield:

: C₈H₁₁N₂O₂S₂^(1-)*K⁽¹⁺⁾

: 1374400-19-7
ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; water / 1 h

1.2: 2.7 h / Reflux

2.1: ethanol; water / 0.02 h / Reflux

In ethanol; water;
DOI:10.1016/j.tet.2013.09.025