ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

Base Information

Chemical Name:ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate
CAS No.:1448182-40-8
Molecular Formula:C₃₃H₃₁N₅O₇S₂
Molecular Weight:673.77
Hs Code.:

ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

Synonyms:ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

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Chemical Property of ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

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Technology Process of ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

There total 4 articles about ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1374400-19-7
ethyl 4-[2-({7-hydroxy-3-[(3-methoxypropyl)carbamoyl]-5-oxo-4H,5H-thieno[3,2-b]pyridin-2-yl}sulfanyl)acetamido]benzoate

: 100-52-7
benzaldehyde

: 109-77-3
malononitrile

: 1448182-40-8
ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

Guidance literature:: With triethylamine; In ethanol; for 0.5h; Reflux;
DOI:10.1016/j.tet.2013.09.025

Reference yield:

: C₈H₁₁N₂O₂S₂^(1-)*K⁽¹⁺⁾

: 1448182-40-8
ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 1 h

1.2: 2.7 h / Reflux

2.1: ethanol; water / 0.02 h / Reflux

3.1: triethylamine / ethanol / 0.5 h / Reflux

With triethylamine; In ethanol; water;
DOI:10.1016/j.tet.2013.09.025

Reference yield:

: 15029-45-5
2-cyano-N-(3-methoxy-propyl) acetamide

: 1448182-40-8
ethyl 4-({[(8-amino-7-cyano-3-{[(3-methoxypropyl)amino]carbonyl}-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridin-2-yl)thio]acetyl}amino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 0.33 h / 10 °C

2.1: ethanol; water / 1 h

2.2: 2.7 h / Reflux

3.1: ethanol; water / 0.02 h / Reflux

4.1: triethylamine / ethanol / 0.5 h / Reflux

With triethylamine; potassium hydroxide; In ethanol; water;
DOI:10.1016/j.tet.2013.09.025