GNE 617

Base Information

• Chemical Name: GNE 617
• CAS No.: 1362154-70-8
• Molecular Formula: C₂₁H₁₅F₂N₃O₃S
• Molecular Weight: 427.431
• Mol file: 1362154-70-8.mol

Synonyms:N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide

Chemical Property of GNE 617

Chemical Property:

Purity/Quality:

98% min ^*data from raw suppliers

GNE-617 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GNE 617

There total 4 articles about GNE 617 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(4-((3,5-difluorophenyl)sulfonyl)phenyl)methanamine (1448536-61-5) + imidazo[1,2-a]pyridine-6-carboxylic acid (139022-25-6) → N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide (1362154-70-8)

Guidance literature:

imidazo[1,2-a]pyridine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 0.416667h;

(4-((3,5-difluorophenyl)sulfonyl)phenyl)methanamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1021/jm4008664

Reference yield:

N-(4-(3,5-difluorophenylsulfonyl)benzyl)acetamide (1448536-58-0) → N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide (1362154-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol / 100 °C

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.42 h / 25 °C

2.2: 16 h / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm4008664

Reference yield:

3,5-difluorophenylboronic acid (156545-07-2) → N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide (1362154-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper diacetate; potassium carbonate / dimethyl sulfoxide / 25 °C / Molecular sieve

2.1: hydrogenchloride / isopropyl alcohol / 100 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.42 h / 25 °C

3.2: 16 h / 25 °C

With hydrogenchloride; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm4008664

upstream raw materials:

3,5-difluorophenylboronic acid

sodium 4-(acetamidomethyl)benzenesulfinate

N-(4-(3,5-difluorophenylsulfonyl)benzyl)acetamide

(4-((3,5-difluorophenyl)sulfonyl)phenyl)methanamine

Refernces