Technology Process of 2-(2-Cyclohexa-1,4-dienyl-ethyl)-isoindole-1,3-dione
There total 1 articles about 2-(2-Cyclohexa-1,4-dienyl-ethyl)-isoindole-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
toluene;
1) 1h ambient temperature 2) 1h reflux;
DOI:10.1021/jo01304a002
- Guidance literature:
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Multi-step reaction with 5 steps
1: 53 percent / m-chloroperoxybenzoic acid / CH2Cl2 / Heating
2: 76 percent / bromine / CH2Cl2 / 2.5 h / -78 °C
3: 94 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / tetrahydrofuran / 24 h / 1) ice bath 2) room temperature
4: 51 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature
5: 92 percent / NaN3 / various solvent(s) / 0.75 h
With
sodium azide; bromine; 3-chloro-benzenecarboperoxoic acid; hydrazine; 1,5-Diazabicyclo[5.4.0]undec-5-ene;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo01304a002
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 12 percent / m-chloroperoxybenzoic acid / CH2Cl2 / Heating
2: 1) N-bromsuccinimide 2) 1,5-diazabicyclo<5.4.0>undec-5-en (DBU) / 1) dibenzoylperoxide, CCl4, 60 min reflux 2) THF, a) cooling with CO2 (s)/CCl4, b) ambient temperature (24h)
3: 11.6 percent / anhydrous hydrazine / CH2Cl2 / 24 h / Ambient temperature
4: tetradeuteriomethanol
With
N-Bromosuccinimide; 3-chloro-benzenecarboperoxoic acid; hydrazine; 1,5-Diazabicyclo[5.4.0]undec-5-ene;
In
dichloromethane; d(4)-methanol;
DOI:10.1021/jo01304a002