Ethoxzolamide

Base Information

Chemical Name:Ethoxzolamide
CAS No.:452-35-7
Molecular Formula:C9H10N2O3S2
Molecular Weight:258.322
Hs Code.:2935009090
European Community (EC) Number:207-199-5
NSC Number:759129,10679
UNII:Z52H4811WX
DSSTox Substance ID:DTXSID1023021
Nikkaji Number:J5.754A
Wikipedia:Ethoxzolamide
Wikidata:Q265352
NCI Thesaurus Code:C65561
Pharos Ligand ID:4A9286PPMZ4F
Metabolomics Workbench ID:42698
ChEMBL ID:CHEMBL18
Mol file:452-35-7.mol

Synonyms:Ethamide;Ethoxazolamide;Ethoxyzolamide;Ethoxzolamide

Suppliers and Price of Ethoxzolamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethoxzolamide
1g
$ 275.00

TRC
Ethoxzolamide
500mg
$ 180.00

Sigma-Aldrich
6-Ethoxy-2-benzothiazolesulfonamide 97%
1g
$ 65.00

ChemScene
Ethoxzolamide 99.43%
100mg
$ 96.00

American Custom Chemicals Corporation
6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE 95.00%
25G
$ 1343.73

American Custom Chemicals Corporation
6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE 95.00%
5G
$ 853.53

American Custom Chemicals Corporation
6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE 95.00%
1G
$ 665.44

Total 48 raw suppliers

Chemical Property of Ethoxzolamide

Chemical Property:

Vapor Pressure:8.05E-09mmHg at 25°C
Melting Point:190-193 °C(lit.)
Refractive Index:1.6800 (estimate)
Boiling Point:464.9°Cat760mmHg
PKA:pKa 8.12(H2O t=25.0) (Uncertain)
Flash Point:235°C
PSA：118.90000
Density:1.47g/cm³
LogP:3.12350
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Ethyl Acetate (Slightly)
Water Solubility.:10.33mg/L(25 oC)
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:258.01328453
Heavy Atom Count:16
Complexity:341

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethoxzolamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N
Uses alcohol dehydrogenase inhibitor, antidote Ethoxzolamide is used in the treatment of glaucoma, and is also used as a diuretic, acting as a carbonic anhydrase inhibitor.
Clinical Use Ethoxzolamide is another carbonic anhydrase inhibitor with properties and uses resembling those of acetazolamide.

Technology Process of Ethoxzolamide

There total 4 articles about Ethoxzolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5304-15-4
6-ethoxy-2-benzothiazolesulfenamide

: 452-35-7
6-ethoxybenzothiazole-2-sulfonamide

Guidance literature:: With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; for 2h;

Reference yield:

: sulfenamide

KMn₀₄: KMn₀₄

: 120-53-6
6-ethoxy-2-mercaptobenzothiazole

: 452-35-7
6-ethoxybenzothiazole-2-sulfonamide

Guidance literature:: With ammonium hydroxide; sodium hypochlorite; In sodium hydroxide; acetone;

Reference yield:

: 120-53-6
6-ethoxy-2-mercaptobenzothiazole

: 452-35-7
6-ethoxybenzothiazole-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: conc. NH₄OH, NaOCl, 2.01 M aq. NaOH / 0.25 h / 0 - 5 °C

2: 80 percent / KMnO₄, 1 N H₂SO₄ / acetone; H₂O / 1 h / pH=8.0 - 8.1

With ammonium hydroxide; sodium hydroxide; sodium hypochlorite; potassium permanganate; sulfuric acid; In water; acetone;
DOI:10.1021/jm00131a011