5304-15-4

Basic information

• Product Name: (6Z)-6-{[(5-chloro-2-methylphenyl)amino]methylidene}-2-ethoxy-4-nitrocyclohexa-2,4-dien-1-one
• CAS NO: 5304-15-4
• Molecular Formula: C₉H₁₀N₂OS₂
• Molecular Weight: 334.7543
• Mol File: 5304-15-4.mol

Chemical Properties

• Boiling Point: 430.7°C at 760 mmHg
• Flash Point: 214.3°C
• Density: 1.34g/cm³
• Vapor Pressure: 1.27E-07mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: (6Z)-6-{[(5-chloro-2-methylphenyl)amino]methylidene}-2-ethoxy-4-nitrocyclohexa-2,4-dien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (6Z)-6-{[(5-chloro-2-methylphenyl)amino]methylidene}-2-ethoxy-4-nitrocyclohexa-2,4-dien-1-one(5304-15-4)
• EPA Substance Registry System: (6Z)-6-{[(5-chloro-2-methylphenyl)amino]methylidene}-2-ethoxy-4-nitrocyclohexa-2,4-dien-1-one(5304-15-4)

Safety Data

• Hazardous Substances Data: 5304-15-4(Hazardous Substances Data)

Upstream product

• 120-53-6 6-ethoxy-2-mercaptobenzothiazole 

Downstream Products

• 121811-03-8 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-04-9 2,6-Dimethoxy-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-00-5 4-Diethylaminomethyl-cyclohexanecarboxylic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 93105-20-5 (2-Sulfamoyl-6-benzothiazolyl) 4-methylphenylsulfonate 
• 121811-05-0 2,4,6-Trimethyl-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-02-7 4-Dimethylaminomethyl-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 86394-95-8 (2-sulfamoyl-6-benzothiazolyl)2-(4-chlorophenyl) acetate 
• 121811-01-6 4-Dimethylamino-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 86394-93-6 2-sulfamoyl-6-benzothiazolyl 2-phenylacetate 
• 86394-97-0 (E)-3-Phenyl-acrylic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 86394-98-1 (2-sulfamoyl-6-benzothiazolyl) cyclohexanecarboxylate 
• 86395-15-5 2-sulfamoyl-6-benzothiazolyl benzoate 
• 29927-14-8 6-hydroxy-2-benzothiazolesulfonamide 
• 452-35-7 6-ethoxybenzothiazole-2-sulfonamide 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR USE IN AUGMENTATION OF GLUCOSE UPTAKE AND INSULIN SECRETION

The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of -S-, -S-S-, -S-(CH2)n-, -NH-, -NH-(CH2)n-, -0-, -S02-, arylene, heteroarylene; Rl is selected from the group consisting of straight or branched C4- C20 alkyl, straight or branched C4-C20 alkenyl, straight or branched C4-C20 alkynyl, each optionally interrupted with at least one NH, C5- C7 saturated cycloalkyl or heteroalkyl ring, C5-C12 aromatic or het- eroaromatic ring, each optionally substituted with at least one group selected from -COOH, -NH2, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 car- boxyl, halogen; and R2 is independently selected from the group consisting of H, OH, SH, NH2, N02, halogen, CN, C1-C8 alkoxy, C1-C5 carboxylic acid, straight or branched C1-C8 alkyl, straight or branched C2-C10 alkenyl, straight or branched C2 - C12 alkynyl each optionally substituted by at least one substituent selected from the group consisting of C1-C5 alkoxy, C1-C5 carboxylic acid, OH, SH, NH2, halogen; and compositions for use in the treatment of diabetes and related dis? orders.

Topically Active Carbonic Anhydrase Inhibitors. 1. O-Acyl Derivatives of 6-Hydroxybenzothiazole-2-sulfonamide

A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonic anhydrase was determined.In vitro studies showed these esters to be substrates for ocular esterases which liberate 4 during corneal translocation.The most interesting series member, 2-sulfamoyl-6-benzothiazolyl 2,2-dimethylpropionate (22, L-645,151), acting as a prodrug form of 4, was found to enhance delivery through the isolated albino rabbit cornea by 40-fold when compared to the parent phenol 4.Studies in rabbits revealed that 22 is a potent topically active ocular hypotensive carbonic anhydrase inhibitor.