methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone

Base Information

• Chemical Name: methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone
• CAS No.: 195251-36-6
• Molecular Formula: C₃₃H₃₁NO₁₁
• Molecular Weight: 617.609
• Mol file: 195251-36-6.mol

Synonyms:methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone

Chemical Property of methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone

There total 3 articles about methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

methyl-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-β-D-manno-2-nonulopyranosidic acid (23755-35-3) + benzoyl chloride (98-88-4) → methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone (195251-36-6) + methyl-5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-2-manno-nonulopyranoside-1,7 lactone

Guidance literature:

In pyridine; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(97)00364-5

Reference yield:

N-Acetyl-β-D-neuraminylsaeure-methyl-methylglycosid (6730-43-4) → methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone (195251-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOH; 2.) Dowex H(+) / H₂O

2: pyridine / 18 h / Ambient temperature

With pyridine; sodium hydroxide; Dowex H(+); In water;

DOI:10.1016/S0040-4039(97)00237-2

Reference yield:

N-acetyl neuraminic acid (6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,489-46-3,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9) → methyl-5-acetamido-7,8,9-tri-O-benzoyl-3,5-dideoxy-β-D-manno-2-nonulopyranoside-1,4 lactone (195251-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / Dowex H(+)

2: 1.) NaOH; 2.) Dowex H(+) / H₂O

3: pyridine / 18 h / Ambient temperature

With pyridine; sodium hydroxide; Dowex H(+); In water;

DOI:10.1016/S0040-4039(97)00237-2

upstream raw materials:

methyl-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-β-D-manno-2-nonulopyranosidic acid

benzoyl chloride

N-Acetyl-β-D-neuraminylsaeure-methyl-methylglycosid

N-acetyl neuraminic acid