methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

Base Information

Chemical Name:methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate
CAS No.:785769-21-3
Molecular Formula:C₂₆H₂₂BrNO₆
Molecular Weight:524.368
Hs Code.:

Synonyms:methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

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Chemical Property of methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

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Technology Process of methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

There total 7 articles about methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402761-42-6
methyl 3-(2-(4-bromobenzyloxy)phenyl)-5-(4-methoxyphenyl-hydroxymethyl)-4,5-dihydroisoxazolo-5-carboxylate

: 785769-21-3
methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jo010895d

Reference yield:

: 101046-14-4
2-((4-bromobenzyl)oxy)benzaldehyde

: 785769-21-3
methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NH₂OH*HCl; NaOAc / tetrahydrofuran; ethanol; H₂O / 6 h / 20 °C

2: bleach containing 5.25percent NaOCl / CH₂Cl₂ / 0 - 20 °C

3: 423 mg / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; sodium acetate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 3: Swern oxidation;
DOI:10.1021/jo010895d

Reference yield:

: 115240-92-1
methyl 2-[hydroxy(4-methoxyphenyl)methyl]prop-2-enoate

: 785769-21-3
methyl 3-(2-((4-bromobenzyl)oxy)phenyl)-5-(4-methoxybenzoyl)-4,5-dihydroisoxazolo-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bleach containing 5.25percent NaOCl / CH₂Cl₂ / 0 - 20 °C

2: 423 mg / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; 2: Swern oxidation;
DOI:10.1021/jo010895d