(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

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Chemical Name:(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester
CAS No.:687636-15-3
Molecular Formula:C₃₀H₄₄N₂O₅S
Molecular Weight:544.756
Hs Code.:

Synonyms:(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

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Chemical Property of (2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

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Technology Process of (2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

There total 17 articles about (2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: tert-butyl (2S,4S,5R)-1-(4-(tert-butyl)-3-methoxybenzoyl)-5-carbamothioyl-2-isobutyl-4-(methoxymethyl)pyrrolidine -2-carboxylate

: 17157-48-1
bromoacetaldehyde

: 687636-15-3
(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

Guidance literature:: tert-butyl (2S,4S,5R)-1-(4-(tert-butyl)-3-methoxybenzoyl)-5-carbamothioyl-2-isobutyl-4-(methoxymethyl)pyrrolidine -2-carboxylate; bromoacetaldehyde; With sodium hydrogencarbonate; In 1,2-dimethoxyethane; at 20 ℃; for 18h;

With pyridine; trifluoroacetic anhydride; In 1,2-dimethoxyethane; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2019.03.019

Reference yield: 57.0%

: 687636-14-2
1,1-dimethylethyl (4S,5R)-1-{[4-(1,1-dimethylethyl)-3-(methyloxy)phenyl]carbonyl}-4-(hydroxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-prolinate

: 74-88-4
methyl iodide

: 687636-15-3
(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

Guidance literature:: 1,1-dimethylethyl (4S,5R)-1-{[4-(1,1-dimethylethyl)-3-(methyloxy)phenyl]carbonyl}-4-(hydroxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-prolinate; With sodium hydride; In N,N-dimethyl-formamide; at -15 ℃; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; at -15 - 10 ℃; for 24h;
DOI:10.1021/jm061207r

Reference yield:

: 74-88-4
methyl iodide

: 687636-15-3
(2S,4S,5R)-2-isobutyl-1-(3-methoxy-4-tert-butylbenzoyl)-4-methoxymethyl-5-(1,3-thiazol-2-yl)-pyrrolidine-2-carboxylic acid 2-tert-butyl ester

Guidance literature:: 1,1-dimethylethyl (4S,5R)-1-{[4-(1,1-dimethylethyl)-3-(methyloxy)phenyl]carbonyl}-4-(hydroxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-prolinate; With sodium hydride; In DMF (N,N-dimethyl-formamide); at -15 ℃; for 0.333333h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at -15 - 10 ℃; for 24h;