(RS)-4--3-(4-chlorophenyl)butanenitrile

Base Information

Chemical Name:(RS)-4--3-(4-chlorophenyl)butanenitrile
CAS No.:229182-25-6
Molecular Formula:C₁₆H₂₁ClN₂O₂
Molecular Weight:308.808
Hs Code.:

(RS)-4-<N-(tert-butyloxycarbonyl)amino>-3-(4-chlorophenyl)butanenitrile

Synonyms:(RS)-4--3-(4-chlorophenyl)butanenitrile

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Chemical Property of (RS)-4--3-(4-chlorophenyl)butanenitrile

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Technology Process of (RS)-4--3-(4-chlorophenyl)butanenitrile

There total 6 articles about (RS)-4--3-(4-chlorophenyl)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 143-33-9,25596-52-5
sodium cyanide

: (RS)-4--3-(4-chlorophenyl)butane

: 229182-25-6
(RS)-4--3-(4-chlorophenyl)butanenitrile

Guidance literature:: In N,N-dimethyl-formamide; at 90 ℃; for 4h;
DOI:10.1021/jm990076+

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 229182-25-6
(RS)-4--3-(4-chlorophenyl)butanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Et₃N / ethanol / a) 0 deg C, 1.5 h, b) 25 deg C, 30 min

2: 78 percent / LiBEt₃H / CH₂Cl₂; tetrahydrofuran / 1.5 h / -30 - 0 °C

3: 97 percent / Ph₃P / CCl₄ / 120 h / Heating

4: 79 percent / dimethylformamide / 4 h / 90 °C

With lithium triethylborohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm990076+

Reference yield:

: 1134-47-0
4-amino-3-(4-chlorophenyl)butanoic acid

: 229182-25-6
(RS)-4--3-(4-chlorophenyl)butanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / HCl

2: 76 percent / Et₃N / ethanol / a) 0 deg C, 1.5 h, b) 25 deg C, 30 min

3: 78 percent / LiBEt₃H / CH₂Cl₂; tetrahydrofuran / 1.5 h / -30 - 0 °C

4: 97 percent / Ph₃P / CCl₄ / 120 h / Heating

5: 79 percent / dimethylformamide / 4 h / 90 °C

With hydrogenchloride; lithium triethylborohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm990076+