1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

Base Information

Chemical Name:1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine
CAS No.:1441793-80-1
Molecular Formula:C₂₃H₂₉Cl₃N₄
Molecular Weight:467.869
Hs Code.:

Synonyms:1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

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Chemical Property of 1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

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Technology Process of 1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

There total 10 articles about 1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1441793-80-1
1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C

1.2: 1 h / 20 °C

2.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 3 h / 110 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.5 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 2 h / 0 °C

5.1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / triethylamine / 18 h / 100 °C / Inert atmosphere

6.1: formic acid; water / 18 h / 60 °C

7.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 80 °C

8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; formic acid; (S)-Mandelic acid; tetrabutyl ammonium fluoride; water; palladium diacetate; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; sodium t-butanolate; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; triethylamine; isopropyl alcohol; toluene;

Reference yield:

: 1441793-74-3
t-butyl 1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-ylcarbamate

: 1441793-80-1
1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1441793-62-9
2-chloro-N-((R)-1-(2,4-dichlorophenyl)ethyl)-5-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)aniline

: 1441793-80-1
1-(1-(4-chloro-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)piperidin-4-yl)pyrrolidin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid; water / 18 h / 60 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With formic acid; water; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;