N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

Base Information

Chemical Name:N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine
CAS No.:1616088-43-7
Molecular Formula:C₂₄H₂₈FNO₆S
Molecular Weight:477.554
Hs Code.:

Synonyms:N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

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Chemical Property of N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

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Technology Process of N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

There total 3 articles about N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1377585-50-6
4-fluoro-N-(methyl(oxo)(phenyl)-λ⁶-sulfanylidene)benzamide

: 140-88-5,9003-32-1
ethyl acrylate

: 1616088-43-7
N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

: 1616088-42-6
N-[2-(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

Guidance literature:: 4-fluoro-N-(methyl(oxo)(phenyl)-λ⁶-sulfanylidene)benzamide; ethyl acrylate; With silver tetrafluoroborate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate hydrate; In 1,2-dichloro-ethane; at 120 ℃; for 24h; Inert atmosphere; Glovebox; Schlenk technique;

With palladium on carbon; hydrogen; In methanol; at 20 ℃; regioselective reaction; Schlenk technique;
DOI:10.1021/jo5008465

Reference yield:

: 1193-82-4
racemic methyl phenyl sulfoxide

: 1616088-43-7
N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

: 1616088-42-6
N-[2-(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; sulfuric acid / chloroform / Schlenk technique

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate hydrate; silver tetrafluoroborate / 1,2-dichloro-ethane / 24 h / 120 °C / Inert atmosphere; Glovebox; Schlenk technique

3.2: 20 °C / Schlenk technique

With dmap; silver tetrafluoroborate; sodium azide; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate hydrate; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; chloroform; 1,2-dichloro-ethane;
DOI:10.1021/jo5008465

Reference yield:

: 4381-25-3
S-methyl-S-phenylsulfoximine

: 1616088-43-7
N-[2,6-di(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

: 1616088-42-6
N-[2-(3-ethoxy-3-oxopropyl)-4-fluorobenzoyl]-S-methyl-S-phenylsulfoximine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate hydrate; silver tetrafluoroborate / 1,2-dichloro-ethane / 24 h / 120 °C / Inert atmosphere; Glovebox; Schlenk technique

2.2: 20 °C / Schlenk technique

With dmap; silver tetrafluoroborate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo5008465