tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate
CAS No.:1603845-24-4
Molecular Formula:C₃₂H₃₈N₈O₅
Molecular Weight:614.704
Hs Code.:

Synonyms:tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.4%

: 1603845-23-3
tert-butyl 4-(4-(4-amino-3-(4-fluoro-3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

: 108-95-2,27073-41-2
phenol

: 1603845-24-4
tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

Reference yield:

: 1603845-21-1
tert-butyl 4-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

: 1603845-24-4
tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 2380-63-4
4-Aminopyrazolo<3,4-d>pyrimidin

: 1603845-24-4
tert-butyl 4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 14 h / 80 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 0.08 h / 0 °C

3.2: 14 h / 20 °C

4.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; di-isopropyl azodicarboxylate; sodium carbonate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;