Pecazine

Base Information

• Chemical Name: Pecazine
• CAS No.: 60-89-9
• Molecular Formula: C19H22 N2 S
• Molecular Weight: 310.463
• Hs Code.: 2934300000
• European Community (EC) Number: 200-490-8
• UNII: PH34873A38
• DSSTox Substance ID: DTXSID2046177
• Nikkaji Number: J46.566F
• Wikipedia: Pecazine
• Wikidata: Q27286554
• NCI Thesaurus Code: C76052
• Pharos Ligand ID: GTX8SA5P6CK1
• ChEMBL ID: CHEMBL395110
• Mol file: 60-89-9.mol

Synonyms:mepazine;mepazine monohydrochloride;mepazine, ion(1+);pecazin

Chemical Property of Pecazine

Chemical Property:

• Vapor Pressure: 4.29E-08mmHg at 25°C
• Melting Point: 80°C
• Refractive Index: 1.6270 (estimate)
• Boiling Point: 444.4°C at 760 mmHg
• Flash Point: 222.6°C
• PSA: 31.78000
• Density: 1.159g/cm³
• LogP: 4.63400
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Water Solubility.: 5.588mg/L(24 oC)
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 310.15036988
• Heavy Atom Count: 22
• Complexity: 352

Purity/Quality:

99%, ^*data from raw suppliers

Pecazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
• Uses: Pecazine Hydrochloride acts as an anti-HIV agent in the form of C-C chemokine inhibitors.
• Therapeutic Function: Tranquilizer

Technology Process of Pecazine

There total 6 articles about Pecazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(chloromethyl)-1-methylpiperidine (52694-50-5) + 10H-phenothiazine (92-84-2) → mepazine (60-89-9)

Guidance literature:

With lithium hexamethyldisilazane; In hexane; toluene; at 80 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2007.03.064

Reference yield:

10H-phenothiazine (92-84-2) → mepazine (60-89-9)

Guidance literature:

Reference yield:

10H-phenothiazine (92-84-2) → mepazine (60-89-9)

Guidance literature:

upstream raw materials:

10H-phenothiazine

3-(chloromethyl)-1-methylpiperidine

Refernces

• 1、 Levy,Tozer,Tuck,Loveland. "Stability of some phenothiazine free radicals.". . p. 898 - 905. Retrieved 2007/10/10.