2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Base Information

Chemical Name:2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile
CAS No.:1440422-13-8
Molecular Formula:C₂₁H₂₁N₅O₄S
Molecular Weight:439.495
Hs Code.:

Synonyms:2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Suppliers and Price of 2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

There total 4 articles about 2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1313279-48-9
2-((1r,4r)-4-aminocyclohexyl)acetonitrile hydrochloride

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1440422-13-8
2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1440422-13-8
2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 5 h / 0 - 23 °C / Inert atmosphere

2: dimethyl sulfoxide / 4 h / 90 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2.5 h / 23 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

With pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm4004895

Reference yield:

: 53292-90-3,130309-46-5,53292-89-0
trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid

: 1440422-13-8
2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / -10 - 15 °C / Inert atmosphere

2: pyridine / dichloromethane / -15 - 25 °C / Inert atmosphere

3: dimethyl sulfoxide / 5 h / 90 °C

4: hydrogenchloride / 1,4-dioxane / 10 - 25 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; dimethylsulfide borane complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;