2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

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Chemical Name:2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile
CAS No.:1440422-20-7
Molecular Formula:C₂₁H₂₃N₅O₂S
Molecular Weight:409.512
Hs Code.:

Synonyms:2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

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Chemical Property of 2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

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Technology Process of 2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

There total 6 articles about 2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1440422-13-8
2-((1r,4r)-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

: 1440422-20-7
2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 80 ℃; under 760.051 Torr; Flow reactor;
DOI:10.1021/acs.jmedchem.9b01439

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1440422-20-7
2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 5 h / 0 - 23 °C / Inert atmosphere

2: dimethyl sulfoxide / 4 h / 90 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2.5 h / 23 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

5: iron; ammonium chloride / ethanol; water / 4 h / Inert atmosphere; Reflux

With pyridine; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm4004895

Reference yield:

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1440422-20-7
2-((1r,4r)-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)cyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

2: iron; ammonium chloride / ethanol; water / 4 h / Inert atmosphere; Reflux

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm4004895