Chemical Property of 3-Deazaadenosine
Chemical Property:
- Vapor Pressure:1.25E-18mmHg at 25°C
- Melting Point:228-229°C
- Boiling Point:665.7ºC at 760 mmHg
- PKA:13.24±0.70(Predicted)
- Flash Point:356.4ºC
- PSA：126.65000
- Density:1.9g/cm3
- LogP:-0.79380
- Storage Temp.:2-8°C
- Solubility.:H2O: 10 mg/mL with heating to 60 °C
- XLogP3:-1.6
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:2
- Exact Mass:266.10150494
- Heavy Atom Count:19
- Complexity:334
- Purity/Quality:
-
98%, *data from raw suppliers
3-Deazaadenosine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CN=C(C2=C1N(C=N2)C3C(C(C(O3)CO)O)O)N
- Isomeric SMILES:C1=CN=C(C2=C1N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N
-
Description
3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.
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Uses
Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
