methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate
CAS No.:1596367-40-6
Molecular Formula:C₂₆H₂₆O₅
Molecular Weight:418.489
Hs Code.:

Synonyms:methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

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Chemical Property of methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

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Technology Process of methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

There total 6 articles about methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1002727-88-9
2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1596367-39-3
methyl 2-(3-benzyloxy-2-bromo-6-methylphenyl)-2-hydroxyacetate

: 1596367-40-6
methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 120 ℃;

Reference yield:

: 1596367-38-2
methyl 2-(2-bromo-3-hydroxy-6-methylphenyl)-2-hydroxyacetate

: 1596367-40-6
methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; sodium iodide / acetone / 0.75 h

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; sodium iodide; In 1,4-dioxane; water; acetone;

Reference yield:

: 1596367-35-9
5-methoxymethox-2-methyl-benzaldehyde

: 1596367-40-6
methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane; toluene / 0.25 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Cooling with ice; Inert atmosphere

1.3: 1.5 h / -78 - 20 °C / Inert atmosphere

2.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3.1: sulfuric acid / 0 °C / Inert atmosphere; Reflux

4.1: caesium carbonate; sodium iodide / acetone / 0.75 h

5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; sodium carbonate; caesium carbonate; sodium iodide; zinc(II) iodide; In 1,4-dioxane; hexane; dichloromethane; water; acetone; toluene;