6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

Base Information

Chemical Name:6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester
CAS No.:125439-35-2
Molecular Formula:C₁₉H₂₁N₅O₄
Molecular Weight:383.407
Hs Code.:

Synonyms:6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

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Chemical Property of 6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

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Technology Process of 6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

There total 3 articles about 6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-[4-(3-Cyano-propoxy)-phenoxymethyl]-nicotinic acid ethyl ester

: 125439-35-2
6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 140 ℃; for 18h;
DOI:10.1021/jm00166a016

Reference yield:

: 40232-83-5
4-(4-hydroxyphenoxy)butanenitrile

: 125439-35-2
6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOH / 1.) ethanol, room temp., 1.5 h, 2a.) room temp., 18 h, 2b.) reflux, 45 min

2: sodium azide, NH₄Cl / dimethylformamide / 18 h / 140 °C

With sodium hydroxide; sodium azide; ammonium chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00166a016

Reference yield:

: 10177-23-8
6-(chloromethyl)-3-pyridinecarboxylic acid ethyl ester

: 125439-35-2
6-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOH / 1.) ethanol, room temp., 1.5 h, 2a.) room temp., 18 h, 2b.) reflux, 45 min

2: sodium azide, NH₄Cl / dimethylformamide / 18 h / 140 °C

With sodium hydroxide; sodium azide; ammonium chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00166a016