(2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

Base Information

Chemical Name:(2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester
CAS No.:1399844-98-4
Molecular Formula:C₂₃H₂₀BrFN₂O₆
Molecular Weight:519.324
Hs Code.:

Synonyms:(2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

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Chemical Property of (2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

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Technology Process of (2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

There total 3 articles about (2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 869569-77-7
1-(4-bromo-2-fluorophenyl)-2-bromo-1-ethanone

: 1399843-77-6
(2S,5S)-5-(methoxycarbonylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid

: 1399844-98-4
(2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 5-(S)-amino-1,2,4,5,6,7-hexahydro-azepino <3,2,1-hi> indole-4-one-2-(S)-carboxylic acid

: 1399844-98-4
(2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; acetonitrile;

Reference yield:

: 204326-24-9
(2S,11S)-11-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-12-oxo-1-azatricyclo[6.4.1.0^[4,13]]trideca-4⁽¹³⁾,5,7-triene-2-carboxylic acid

: 1399844-98-4
(2S,5S)-5-methoxycarbonylamino-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid 2-(4-bromo-2-fluoro-phenyl)-2-oxo-ethylester

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

With piperidine; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;