(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene

Base Information

• Chemical Name: (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene
• CAS No.: 1104662-09-0
• Molecular Formula: C₁₇H₂₄NO₇P
• Molecular Weight: 385.354
• Mol file: 1104662-09-0.mol

Synonyms:(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene

Chemical Property of (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene

There total 1 articles about (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

dimethyl 2-oxo-3-(N-tert-butoxycarbonylamino)propane phosphonate (112392-58-2) + benzoic acid anhydride (93-97-0) → (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene (1104662-09-0)

Guidance literature:

dimethyl 2-oxo-3-(N-tert-butoxycarbonylamino)propane phosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

benzoic acid anhydride; With dmap; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201000611

Reference yield: 87.0%

(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene (1104662-09-0) → (R)-2-benzoyloxy-3-(N-tert-butoxycarbonylamino)-1-dimethoxyphosphorylpropane (1104662-18-1)

Guidance literature:

With BF₄^(1-)*C₈H₁₂*C₄₂H₄₆O₃P₂*Rh⁽¹⁺⁾; hydrogen; In dichloromethane; at 25 ℃; for 24h; under 3040.2 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.200801588

Reference yield: 87.0%

(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-3-[N-(tertbutoxycarbonyl)amino]-1-propene (1104662-09-0) → (R)-2-benzoyloxy-3-(N-tert-butoxycarbonylamino)-1-dimethoxyphosphorylpropane (1104662-18-1) + C10H22NO5P

Guidance literature:

With BF₄^(1-)*C₄₄H₆₃IrO₃P₂⁽²⁺⁾; hydrogen; In dichloromethane; at 25 ℃; for 24h; under 3040.2 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.201000611

upstream raw materials:

dimethyl 2-oxo-3-(N-tert-butoxycarbonylamino)propane phosphonate

benzoic acid anhydride

Downstream raw materials:

(R)-2-benzoyloxy-3-(N-tert-butoxycarbonylamino)-1-dimethoxyphosphorylpropane