3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

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Chemical Name:3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
CAS No.:1048035-16-0
Molecular Formula:C₂₈H₃₄ClFN₄O₃S
Molecular Weight:561.12
Hs Code.:

Synonyms:3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

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Chemical Property of 3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

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Technology Process of 3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

There total 10 articles about 3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1048034-94-1
(2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-phenyl)-methanol

: 459-46-1
4-Fluorobenzyl bromide

: 1048035-16-0
3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 18h;

Reference yield:

: 1048034-93-0
C₁₁H₂₀N₂O₂S

: 1048035-16-0
3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

1.2: 18 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

3.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

4.1: acetic acid / dichloromethane / 0.17 h

4.2: 60 h

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 4.5 h / 0 - 20 °C

6.1: sodium tetrahydroborate / ethanol / 6 h

7.1: sodium hydride / tetrahydrofuran / 18 h

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydride; diisobutylaluminium hydride; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1048035-05-7
C₁₇H₁₇ClN₄O₃S

: 1048035-16-0
3-[4-chloro-3-(4-fluoro-benzyloxymethyl)-phenyl]-5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 0.17 h

1.2: 60 h

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 4.5 h / 0 - 20 °C

3.1: sodium tetrahydroborate / ethanol / 6 h

4.1: sodium hydride / tetrahydrofuran / 18 h

With sodium tetrahydroborate; sodium hydride; diisobutylaluminium hydride; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;