2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

Base Information

Chemical Name:2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile
CAS No.:1048034-83-8
Molecular Formula:C₁₄H₁₃ClN₄O₂S
Molecular Weight:336.802
Hs Code.:

Synonyms:2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

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Chemical Property of 2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

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Technology Process of 2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

There total 3 articles about 2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1048034-93-0
C₁₁H₂₀N₂O₂S

: 181283-43-2
4-chloro-3-cyanobenzoyl chloride

: 1048034-83-8
2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

Guidance literature:: C₁₁H₂₀N₂O₂S; 4-chloro-3-cyanobenzoyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

With hydrazine; In ethanol; at 0 - 20 ℃; for 18h;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1048034-83-8
2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / chloroform; water / 73 h / 0 °C

2.1: toluene-4-sulfonic acid / benzene / 20 h / Heating / reflux

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; chloroform; water; benzene;

Reference yield:

: 218780-53-1
1-(methylsulfonyl)piperidin-4-one

: 1048034-83-8
2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / benzene / 20 h / Heating / reflux

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2.2: 18 h / 0 - 20 °C

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; benzene;