(2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

Base Information

Chemical Name:(2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine
CAS No.:1358465-22-1
Molecular Formula:C₂₁H₂₂F₃NO₂
Molecular Weight:377.406
Hs Code.:

Synonyms:(2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

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Chemical Property of (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

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Technology Process of (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

There total 5 articles about (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1358465-41-4
(2R,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine

: 100-39-0
benzyl bromide

: 1358465-22-1
(2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

Guidance literature:: (2R,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -78 ℃; for 4h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2011.02.020

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1358465-22-1
(2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / toluene / 20 h / Reflux

2.1: boron trifluoride diethyl etherate / dichloromethane / 24 h / 20 °C

3.1: 36 h / 50 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 4 h / -78 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.jfluchem.2011.02.020

Reference yield:

: 1358465-35-6
(2R,4R)-2-methyl-2-trifluoromethyl-4-phenyloxazolidine

: 1358465-22-1
(2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 36 h / 50 °C

2.1: lithium aluminium tetrahydride

3.1: 67 h / 60 °C / neat (no solvent)

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 4 h / -78 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.jfluchem.2011.02.020