(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate
CAS No.:1338327-24-4
Molecular Formula:C₁₅H₁₃F₃N₄O₅S
Molecular Weight:418.353
Hs Code.:

Synonyms:(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

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Chemical Property of (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

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Technology Process of (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

There total 8 articles about (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.3%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1338327-25-5
(R)-4-amino-6-(4-hydroxyphenyl)-8-methyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

: 1338327-24-4
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 18 - 25 ℃; for 3h;

Reference yield:

: 6793-92-6
p-benzyloxyphenylbromide

: 1338327-24-4
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / palladium diacetate; XPhos / toluene / 10 h / 120 °C / Microwave irradiation; Sealed tube

2: triethylamine / tetrahydrofuran / 16.17 h / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 0.75 h / 20 °C

4: potassium carbonate / acetonitrile / 66 h / 80 - 85 °C / Microwave irradiation; Sealed tube

5: ammonia / 1,4-dioxane / 48 h / 55 °C

6: hydrogen / palladium(II) hydroxide / methanol / 1 h / 18 - 25 °C / 760.05 Torr

7: potassium carbonate / tetrahydrofuran / 3 h / 18 - 25 °C

With hydrogenchloride; ammonia; hydrogen; potassium carbonate; caesium carbonate; triethylamine; palladium diacetate; palladium(II) hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; acetonitrile;

Reference yield:

: 87600-97-3
4,6-dichloropyrimidine-5-carboxylic acid chloride

: 1338327-24-4
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 16.17 h / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 0.75 h / 20 °C

3: potassium carbonate / acetonitrile / 66 h / 80 - 85 °C / Microwave irradiation; Sealed tube

4: ammonia / 1,4-dioxane / 48 h / 55 °C

5: hydrogen / palladium(II) hydroxide / methanol / 1 h / 18 - 25 °C / 760.05 Torr

6: potassium carbonate / tetrahydrofuran / 3 h / 18 - 25 °C

With hydrogenchloride; ammonia; hydrogen; potassium carbonate; triethylamine; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;