<1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran

Base Information

• Chemical Name: <1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran
• CAS No.: 116558-69-1
• Molecular Formula: C₁₈H₃₀O₃
• Molecular Weight: 294.434
• Mol file: 116558-69-1.mol

Synonyms:<1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran

Chemical Property of <1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran

There total 17 articles about <1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1S,2R,5S)-(+)-menthol (15356-60-2) + <3aR-(3aα,4α,7α,7aα)>-hydroxyhexahydro-4,7-epoxyisobenzofuran (70120-28-4,70145-02-7,74868-28-3,96444-25-6,98717-62-5,98717-69-2,98717-70-5,98717-94-3,98717-99-8,98718-05-9,98718-12-8,98718-14-0,98718-15-1) → <1R-<1α(1S,2R,5S),3aα,4α,7α,7aα>>-1-<5-methyl-2-(1-methylethyl)cylohexyloxy>-octahydro-4,7-epoxyisobenzofuran (116558-69-1)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 3h; Heating;

DOI:10.1055/s-1987-28183

Reference yield: 45.0%

(-)-menthol (2216-51-5) + endo-octahydro-4,7-epoxyisobenzofuran-1-ol (70120-28-4,70145-02-7,74868-28-3,96444-25-6,98717-62-5,98717-69-2,98717-70-5,98717-94-3,98717-99-8,98718-05-9,98718-12-8,98718-14-0,98718-15-1) → (1R,2R,6R,7S)-3-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-4,10-dioxa-tricyclo[5.2.1.02,6]decane (96410-99-0,96444-17-6,96444-18-7,98717-63-6,98717-64-7,98717-65-8,98717-66-9,116558-69-1,116558-70-4) + (1S,2S,6S,7R)-3-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-4,10-dioxa-tricyclo[5.2.1.02,6]decane (96410-99-0,96444-17-6,96444-18-7,98717-63-6,98717-64-7,98717-65-8,98717-66-9,116558-69-1,116558-70-4)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 18h; Heating;

DOI:10.1021/jm00149a007

Reference yield: 45.0%

(-)-menthol (2216-51-5) + endo-octahydro-4,7-epoxyisobenzofuran-1-ol (70120-28-4,70145-02-7,74868-28-3,96444-25-6,98717-62-5,98717-69-2,98717-70-5,98717-94-3,98717-99-8,98718-05-9,98718-12-8,98718-14-0,98718-15-1) → (1R,2R,6R,7S)-3-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-4,10-dioxa-tricyclo[5.2.1.02,6]decane (96410-99-0,96444-17-6,96444-18-7,98717-63-6,98717-64-7,98717-65-8,98717-66-9,116558-69-1,116558-70-4) + (1S,2S,6S,7R)-3-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-4,10-dioxa-tricyclo[5.2.1.02,6]decane (96410-99-0,96444-17-6,96444-18-7,98717-63-6,98717-64-7,98717-65-8,98717-66-9,116558-69-1,116558-70-4)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 18h; Heating;

DOI:10.1021/jm00149a007

upstream raw materials:

(1S,2R,5S)-(+)-menthol

(3aα,4α,7α,7aα)-1-hydroxyhexahydro-4,7-epoxyisobenzofuran

<3aR-(3aα,4α,7α,7aα)>-hydroxyhexahydro-4,7-epoxyisobenzofuran

<3aR-(3aα,4α,7α,7aα)>-hexahydro-4,7-epoxyisobenzofuran-1-(3H)-one

Downstream raw materials:

[3aS-(3aα,4α,7α,7aα)]-Octahydro-1-benzyloxy-4,7-epoxyisobenzofuran