dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

Base Information

Chemical Name:dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate
CAS No.:925684-67-9
Molecular Formula:C₁₄H₂₂BrNO₇P₂
Molecular Weight:458.183
Hs Code.:

Synonyms:dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

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Chemical Property of dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

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Technology Process of dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

There total 4 articles about dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 925684-66-8
dimethyl 2-(4-aminophenyl)-1-(dimethoxyphosphoryl)ethylphosphonate

: 598-21-0
2-Bromoacetyl bromide

: 925684-67-9
dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

Guidance literature:: With pyridine; In dichloromethane; for 4h; Cooling with ice;
DOI:10.1016/j.bmc.2008.09.010

Reference yield:

: 925684-64-6
dimethyl 1-(dimethoxyphosphoryl)-2-(4-nitrophenyl)ethylphosphonate

: 925684-67-9
dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / platinum(IV) oxide / ethanol / 14 h / 2844.39 Torr

2: pyridine / dichloromethane / 4 h / 0 °C

With pyridine; hydrogen; platinum(IV) oxide; In ethanol; dichloromethane;

Reference yield:

: 16001-93-7
tetramethyl methylenediphosphonate

: 925684-67-9
dimethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(dimethoxyphosphoryl)ethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

1.2: 4.5 h / 20 °C

2.1: hydrogen / platinum(IV) oxide / ethanol / 14 h / 2844.39 Torr

3.1: pyridine / dichloromethane / 4 h / 0 °C

With pyridine; hydrogen; sodium hydride; platinum(IV) oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;