TETRAMETHYL METHYLENEDIPHOSPHONATE

Base Information

• Chemical Name: TETRAMETHYL METHYLENEDIPHOSPHONATE
• CAS No.: 16001-93-7
• Molecular Formula: C5H14 O6 P2
• Molecular Weight: 232.11
• Hs Code.: 2916190090
• Mol file: 16001-93-7.mol

Synonyms:Phosphonicacid, methylenebis-, tetramethyl ester (9CI); Phosphonic acid, methylenedi-,tetramethyl ester (8CI); Tetramethyl methanediphosphonate; Tetramethylmethylenebisphosphonate; Tetramethyl methylenediphosphonate

Chemical Property of TETRAMETHYL METHYLENEDIPHOSPHONATE

Chemical Property:

• Vapor Pressure: 0.00203mmHg at 25°C
• Refractive Index: 1.4550
• Boiling Point: 300.2°Cat760mmHg
• Flash Point: 149.2°C
• PSA: 90.68000
• Density: 1.255g/cm³
• LogP: 1.91570
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Sparingly), Methanol (Sparingly)
• Water Solubility.: Miscible with water.

Purity/Quality:

98%Min ^*data from raw suppliers

TetramethylMethylenebis(phosphonate) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:Harmful if swallowed.; R36/38:Irritating to eyes and skin.
• Hazard Codes: R22:Harmful if swallowed.; R36/38:Irritating to eyes and skin.
• Statements: 22
• Safety Statements: 23-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tetramethyl methylenediphosphonate is used in the preparation of phosphonate analogue of ribose-1-phosphate.

Technology Process of TETRAMETHYL METHYLENEDIPHOSPHONATE

There total 4 articles about TETRAMETHYL METHYLENEDIPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Methylenediphosphonic acid (1984-15-2) + trimethyl orthoformate (149-73-5) → tetramethyl methylenediphosphonate (16001-93-7)

Guidance literature:

for 15h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2021.153012

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + Dimethyl phosphite (868-85-9) → dimethylthiophosphoric acid (1112-38-5) + tetramethyl methylenediphosphonate (16001-93-7)

Guidance literature:

Dimethyl phosphite; With sodium hydride; In tetrahydrofuran; at -5 - 20 ℃; Inert atmosphere;

carbon disulfide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1080/10426500802715528

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + Methylenediphosphonic acid (1984-15-2) → tetramethyl methylenediphosphonate (16001-93-7)

Guidance literature:

In diethyl ether;

DOI:10.1071/CH9670503

upstream raw materials:

diazomethane

Methylenediphosphonic acid

Tetraisopropyl methylenediphosphonate

trimethyl orthoformate

Downstream raw materials:

D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

D-allo-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

tetrabenzyl methylenediphosphonate

2,3,4,6-Tetra-O-benzyl-D-glucopyranose