tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate
CAS No.:1372671-38-9
Molecular Formula:C₃₅H₃₆F₂N₄O₇
Molecular Weight:662.69
Hs Code.:

tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

Synonyms:tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

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Chemical Property of tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

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Technology Process of tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

There total 5 articles about tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 849217-50-1
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 112663-43-1
3-(tert-butoxycarbonylamino)propyl methanesulfonate

: 1372671-38-9
tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1372671-38-9
tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: N,N-dimethyl-formamide / 20 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1372671-34-5
4-(4-amino-2-fluorophenyloxy)-6-methoxy-7-hydroxyquinoline hydrobromide

: 1372671-38-9
tert-butyl N-[3-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]propyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU; dmap / N,N-dimethyl-formamide / 30 - 40 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With dmap; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;